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1

Insights into Insulin Fibril Assembly at Physiological and Acidic pH and Related Amyloid Intrinsic Fluorescence

Iannuzzi, Clara, Borriello, Margherita, Portaccio, Marianna, Irace, Gaetano, Sirangelo, Ivana

Journal:

International Journal of Molecular Sciences

Year:

2017

Language:

english

File:

PDF, 3.54 MB

english, 2017

2

Tryptophanyl substitutions in apomyoglobin affect conformation and dynamic properties of AGH subdomain

Ivana Sirangelo, Clara Iannuzzi, Clorinda Malmo, Gaetano Irace

Journal:

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

3

W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac

Ivana Sirangelo, Clara Iannuzzi, Silvia Vilasi, Gaetano Irace, Gaia Giuberti, Gabriella Misso, Annamaria D'Alessandro, Alberto Abbruzzese, Michele Caraglia

Journal:

Journal of Cellular Physiology

Year:

2009

Language:

english

File:

PDF, 584 KB

english, 2009

4

Fluorescence lifetime distribution of 1,8-anilinonaphthalenesulfonate (ANS) in reversed micelles detected by frequency domain fluorometry

Ettore Bismuto, Ivana Sirangelo, Gaetano Irace

Journal:

Biophysical Chemistry

Year:

1992

Language:

english

File:

PDF, 608 KB

english, 1992

5

The effect of tryptophanyl substitution on folding and structure of myoglobin

Ivana Sirangelo, Simona Tavassi, Pier Luigi Martelli, Rita Casadio, Gaetano Irace

Journal:

Year:

2000

Language:

english

File:

PDF, 3.36 MB

english, 2000

6

Pressure-induced perturbation of ANS-apomyoglobin complex: Frequency domain fluorescence studies on native and acidic compact states

Ettore Bismuto, Gaetano Irace, Ivana Sirangelo, Enrico Gratton

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 640 KB

english, 1996

7

Dynamic fluorescence of extrinsic fluorophores as a tool for studying protein conformational substates

Ettore Bismuto, Ivana Sirangelo, Adalgisa Adinolfi, Gaetano Irace

Journal:

Year:

1990

Language:

english

File:

PDF, 225 KB

english, 1990

8

Near-ultraviolet circular dichroic activity of apomyoglobin: resolution of the individual tryptophanyl contributions by site-directed mutagenesis

Ivana Sirangelo, Ettore Bismuto, Simona Tavassi, G. Irace

Journal:

European Biophysics Journal

Year:

1998

Language:

english

File:

PDF, 130 KB

english, 1998

9

Heme binding inhibits the fibrillization of amyloidogenic apomyoglobin and determines lack of aggregate cytotoxicity

Clara Iannuzzi, Silvia Vilasi, Marianna Portaccio, Gaetano Irace, Ivana Sirangelo

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 445 KB

english, 2007

10

Resolution of Tryptophan–ANS Fluorescence Energy Transfer in Apomyoglobin by Site-directed Mutagenesis

Ivana Sirangelo, Clorinda Malmo, Mariateresa Casillo, Gaetano Irace

Journal:

Photochemistry and Photobiology

Year:

2002

Language:

english

File:

PDF, 139 KB

english, 2002

11

Effect of Trehalose on W7FW14F Apomyoglobin and Insulin Fibrillization: New Insight into Inhibition Activity†

Vilasi, Silvia, Iannuzzi, Clara, Portaccio, Marianna, Irace, Gaetano, Sirangelo, Ivana

Journal:

Year:

2008

Language:

english

File:

PDF, 283 KB

english, 2008

12

Resolution of the effects induced by W

Infusini, Giuseppe, Iannuzzi, Clara, Vilasi, Silvia, Birolo, Leila, Pagnozzi, Daniela, Pucci, Piero, Irace, Gaetano, Sirangelo, Ivana

Journal:

European Biophysics Journal

Year:

2012

Language:

english

File:

PDF, 604 KB

english, 2012

13

Apomyoglobin folding intermediates characterized by the hydrophobic fluorescent probe 8-anilino-1-naphthalene sulfonate (ANS)

Ivana Sirangelo, Ettore Bismuto, Simona Tavassi, Gaetano Irace

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1998

Language:

english

File:

PDF, 172 KB

english, 1998

14

Tryptophanyl contributions to apomyoglobin fluorescence resolved by site-directed mutagenesis

Ivana Sirangelo, Simona Tavassi, Gaetano Irace

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

2000

Language:

english

File:

PDF, 275 KB

english, 2000

15

RESOLUTION OF THE INDIVIDUAL TRYPTOPHANYL CONTRIBUTIONS TO THE NEAR-ULTRAVIOLET DICHROIC ACTIVITY OF APOMYOGLOBIN

Ivana Sirangelo, Gaetano Irace, Ettore Bismuto

Journal:

Photochemistry and Photobiology

Year:

1994

Language:

english

File:

PDF, 357 KB

english, 1994

16

RESOLUTION OF THE INDIVIDUAL TRYPTOPHANYL CONTRIBUTIONS TO THE NEAR-ULTRAVIOLET DICHROIC ACTIVITY OF APOMYOGLOBIN

IVANA SIRANGELO, GAETANO IRACE, ETTORE BISMUTO

Journal:

Photochemistry and Photobiology

Year:

1994

Language:

english

File:

PDF, 757 KB

english, 1994

17

Structure and dynamics of the acidic compact state of apomyoglobin by frequency-domain fluorometry

Ettore BISMUTO, Enrico GRATTON, Ivana SIRANGELO, Gaetano IRACE

Journal:

Year:

1993

Language:

english

File:

PDF, 657 KB

english, 1993

18

Molecular organization and dynamics of the outer membrane of Salmonella thyphimurium mutant strains detected by frequency domain fluorometry

Ettore Bismuto, Ivana Sirangelo, Adalgisa Adinolfi, Francesco Galdiero, Maria Antonietta Tufano, Linda Sommese, Gaetano Irace

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 639 KB

english, 1991

19

Salt-induced refolding of myoglobin at acidic pH: Molecular properties of a partly folded intermediate

Ettore Bismuto, Ivana Sirangelo, Gaetano Irace

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 735 KB

english, 1992

20

Folding and dynamics of melittin in reversed micelles

Ettore Bismuto, Ivana Sirangelo, Gaetano Irace

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1993

Language:

english

File:

PDF, 593 KB

english, 1993

21

Solvent and thermal denaturation of the acidic compact state of apomyoglobin

Ivana Sirangelo, Ettore Bismuto, Gaetano Irace

Journal:

Year:

1994

Language:

english

File:

PDF, 551 KB

english, 1994

22

Mutations in the NKXD consensus element indicate that GTP binds to the γ-subunit of translation initiation factor eIF2

Tatjana Naranda, Ivana Sirangelo, Bradon J. Fabbri, John W.B. Hershey

Journal:

Year:

1995

Language:

english

File:

PDF, 398 KB

english, 1995

23

Kinetics of amyloid aggregation of mammal apomyoglobins and correlation with their amino acid sequences

Silvia Vilasi, Roberta Dosi, Clara Iannuzzi, Clorinda Malmo, Augusto Parente, Gaetano Irace, Ivana Sirangelo

Journal:

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

24

Higher susceptibility to amyloid fibril formation of the recombinant ovine prion protein modified by transglutaminase

Angela Sorrentino, Concetta Valeria L. Giosafatto, Ivana Sirangelo, Carmela De Simone, Prospero Di Pierro, Raffaele Porta, Loredana Mariniello

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2012

Language:

english

File:

PDF, 762 KB

english, 2012

25

Stachydrine ameliorates high-glucose induced endothelial cell senescence and SIRT1 downregulation

Servillo, Luigi, D'Onofrio, Nunzia, Longobardi, Lara, Sirangelo, Ivana, Giovane, Alfonso, Cautela, Domenico, Castaldo, Domenico, Giordano, Antonio, Balestrieri, Maria Luisa

Journal:

Journal of Cellular Biochemistry

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

26

Amyloid toxicity and platelet-activating factor signaling

Sirangelo, Ivana, Irace, Gaetano, Balestrieri, Maria Luisa

Journal:

Journal of Cellular Physiology

Year:

2013

Language:

english

File:

PDF, 315 KB

english, 2013

27

Time-Resolved Small-Angle X-Ray Scattering Study of the Early Formation of Amyloid Protofibrils on a Apomyoglobin Mutant

Ortore, Maria Grazia, Spinozzi, Francesco, Vilasi, Silvia, Sirangelo, Ivana, Irace, Gaetano, Shukla, Anuji, Narayanan, Theyencheri, Sinibaldi, Raffaele, Mariani, Paolo

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 37 KB

english, 2011

28

Hexafluoroisopropanol and Acid Destabilized Forms of Apomyoglobin Exhibit Structural Differences †

Sirangelo, Ivana, Dal Piaz, Fabrizio, Malmo, Clorinda, Casillo, Mariateresa, Birolo, Leila, Pucci, Piero, Marino, Gennaro, Irace, Gaetano

Journal:

Year:

2003

Language:

english

File:

PDF, 233 KB

english, 2003

29

Conformational substates of myoglobin detected by extrinsic dynamic fluorescence studies

Bismuto, Ettore, Sirangelo, Ivana, Irace, Gaetano

Journal:

Year:

1989

Language:

english

File:

PDF, 1.07 MB

english, 1989

30

Pressure-Induced Perturbation of Apomyoglobin Structure: Fluorescence Studies on Native and Acidic Compact Forms †

Bismuto, Ettore, Sirangelo, Ivana, Irace, Gaetano, Gratton, Enrico

Journal:

Year:

1996

Language:

english

File:

PDF, 537 KB

english, 1996

31

Time-resolved small-angle x-ray scattering study of the early stage of amyloid formation of an apomyoglobin mutant

Ortore, Maria Grazia, Spinozzi, Francesco, Vilasi, Silvia, Sirangelo, Ivana, Irace, Gaetano, Shukla, Anuj, Narayanan, Theyencheri, Sinibaldi, Raffaele, Mariani, Paolo

Journal:

Physical Review E

Year:

2011

Language:

english

File:

PDF, 581 KB

english, 2011

32

Unraveling amyloid toxicity pathway in NIH3T3 cells by a combined proteomic and 1 H-NMR metabonomic approach

Vilasi, Annalisa, Vilasi, Silvia, Romano, Rocco, Acernese, Fausto, Barone, Fabrizio, Balestrieri, Maria Luisa, Maritato, Rosa, Irace, Gaetano, Sirangelo, Ivana

Journal:

Journal of Cellular Physiology

Year:

2013

Language:

english

File:

PDF, 2.40 MB

english, 2013

33

Platelet-Activating Factor Mediates the Cytotoxicity Induced by W7FW14F Apomyoglobin Amyloid Aggregates in Neuroblastoma Cells

Sirangelo, Ivana, Giovane, Alfonso, Maritato, Rosa, Nunzia, D'Onofrio, Iannuzzi, Clara, Giordano, Antonio, Irace, Gaetano, Balestrieri, Maria Luisa

Journal:

Journal of Cellular Biochemistry

Year:

2014

Language:

english

File:

PDF, 359 KB

english, 2014

34

Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose

Sirangelo, Ivana, Irace, Gaetano

Journal:

Expert Opinion on Therapeutic Targets

Year:

2010

Language:

english

File:

PDF, 402 KB

english, 2010

35

Glycation of Wild-Type Apomyoglobin Induces Formation of Highly Cytotoxic Oligomeric Species

Iannuzzi, Clara, Carafa, Vincenzo, Altucci, Lucia, Irace, Gaetano, Borriello, Margherita, Vinciguerra, Roberto, Sirangelo, Ivana

Journal:

Journal of Cellular Physiology

Year:

2015

Language:

english

File:

PDF, 1.92 MB

english, 2015

36

Resolution of Tryptophan–ANS Fluorescence Energy Transfer in Apomyoglobin by Site-directed Mutagenesis¶

Sirangelo, Ivana, Malmo, Clorinda, Casillo, Mariateresa, Irace, Gaetano

Journal:

Photochemistry and Photobiology

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

37

D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts

Iannuzzi, Clara, Borriello, Margherita, Carafa, Vincenzo, Altucci, Lucia, Vitiello, Milena, Balestrieri, Marialuisa, Ricci, Giulia, Irace, Gaetano, Sirangelo, Ivana

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2015

Language:

english

File:

PDF, 2.09 MB

english, 2015

38

Differential effects of glycation on protein aggregation and amyloid formation

Iannuzzi, Clara, Irace, Gaetano, Sirangelo, Ivana

Journal:

Frontiers in Molecular Biosciences

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

39

The Effect of Glycosaminoglycans (GAGs) on Amyloid Aggregation and Toxicity

Iannuzzi, Clara, Irace, Gaetano, Sirangelo, Ivana

Journal:

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

40

Vanillin Affects Amyloid Aggregation and Non-Enzymatic Glycation in Human Insulin

Iannuzzi, Clara, Borriello, Margherita, Irace, Gaetano, Cammarota, Marcella, Di Maro, Antimo, Sirangelo, Ivana

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.29 MB

english, 2017

41

Urinary sucrose and fructose to validate self-reported sugar intake in children and adolescents: results from the I.Family study

Intemann, Timm, Pigeot, Iris, De Henauw, Stefaan, Eiben, Gabriele, Lissner, Lauren, Krogh, Vittorio, Dereń, Katarzyna, Molnár, Dénes, Moreno, Luis A., Russo, Paola, Siani, Alfonso, Sirangelo, Ivana, T

Journal:

European Journal of Nutrition

Year:

2018

Language:

english

File:

PDF, 730 KB

english, 2018

42

Glycation Accelerates Fibrillization of the Amyloidogenic W7FW14F Apomyoglobin

Iannuzzi, Clara, Maritato, Rosa, Irace, Gaetano, Sirangelo, Ivana, Pastore, Annalisa

Journal:

Year:

2013

Language:

english

File:

PDF, 1.97 MB

english, 2013

43

Misfolding and Amyloid Aggregation of Apomyoglobin

Iannuzzi, Clara, Maritato, Rosa, Irace, Gaetano, Sirangelo, Ivana

Journal:

International Journal of Molecular Sciences

Year:

2013

Language:

english

File:

PDF, 458 KB

english, 2013

44

Glycation in Demetalated Superoxide Dismutase 1 Prevents Amyloid Aggregation and Produces Cytotoxic Ages Adducts

Sirangelo, Ivana, Vella, Filomena M., Irace, Gaetano, Manco, Giuseppe, Iannuzzi, Clara

Journal:

Frontiers in Molecular Biosciences

Year:

2016

Language:

english

File:

PDF, 1.86 MB

english, 2016

45

Protective effect of extractive and biotechnological chondroitin in insulin amyloid and advanced glycation end product-induced toxicity

Iannuzzi, Clara, Borriello, Margherita, D’Agostino, Antonella, Cimini, Donatella, Schiraldi, Chiara, Sirangelo, Ivana

Journal:

Journal of Cellular Physiology

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

46

Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin

Sirangelo, Ivana, Borriello, Margherita, Vilasi, Silvia, Iannuzzi, Clara

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 2.73 MB

2020

47

Vanillin Prevents Doxorubicin-Induced Apoptosis and Oxidative Stress in Rat H9c2 Cardiomyocytes

Sirangelo, Ivana, Sapio, Luigi, Ragone, Angela, Naviglio, Silvio, Iannuzzi, Clara, Barone, Daniela, Giordano, Antonio, Borriello, Margherita

Journal:

Year:

2020

File:

PDF, 1.95 MB

2020